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TEACHING STAFF
Organised by:
 LEON AARONS
is a Professor of Pharmacometrics in the School of Pharmacy and Pharmaceutical Sciences, University of Manchester, UK.
Research:
Population pharmacokinetics (PK) and pharmacodynamics (PD) aims to investigate and quantify PK/PD differences between patients. Population PK/PD is a modelling discipline and we use a variety of Maximum Likelihood and Bayesian techniques to perform the modelling. Current therapeutic applications include malaria, paediatrics, anti-inflammatories and anti-cancer agents. Computer aided clinical trial design (CATD) builds on population modelling and is a model based technique in which future clinical trials are designed based on the current state of knowledge using stochastic simulation techniques. The work is carried out within CAPKR. The methodology has been applied to an anti-migraine drug. The use of optimal design techniques is an alternative to CATD and aims to minimise parameter estimation error using various information criteria. Both frequentist and Bayesian methods are being applied. This work is also being carried out in CAPKR and we are currently working on both the methodology and developing software.
| JEFFREY ARONSON
is Reader in Clinical Pharmacology, University of Oxford, and Hon. Consultant Physician to the Oxford Radcliffe Hospitals Trust. He is President Emeritus of the British Pharmacological Society.
Research:
Clinical pharmacology of cardiac glycosides; physiology and pathophysiology of the sodium/potassium pump, potassium channels and other ion transport systems; pharmacokinetics of monovalent and divalent cations; adverse drug reactions.
| BRIAN HOUSTON
is
Professor in the School of Pharmacy and Pharmaceutical Sciences, University of Manchester.
Research:
Prediction of in vivo clearance from various in vitro drug metabolism data, the molecular/kinetic basis for drug/drug interactions (inhibition, activation and induction), interrelationship between transport and metabolic systems, human CYP3A enzymes, genotypic/phenotypic sources of variability in human drug metabolising enzymes.
| GEOFFREY TUCKER
is Emeritus Professor of Clinical Pharmacology, University of Sheffield UK and Chairman of Simcyp Ltd. He is the author of over 300 research articles, reviews, books and book chapters. Professor Tucker is an honorary fellow of the Royal College of Anaesthetists UK, of the Royal College of Physicians of Edinburgh, of the Faculty of Pharmaceutical Medicine, Royal College of Physicians UK, of the British Pharmacological Society, of the British Toxicological Society and of the American College of Clinical Pharmacology. He is currently a Vice-President of the Board of Pharmaceutical Sciences of the International Pharmaceutical Federation (FIP) and a Councillor of the International Society for the Study of Xenobiotics (ISSX).
Research:
His main research interests are clinical and theoretical pharmacokinetics and human drug metabolism in general, and specifically the prediction of pharmacokinetics and drug interactions using in vitro-in vivo extrapolation and physiologically based PK modelling.
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